Shani Jones, 4, has a curable form of leukemia but it will take a lot of blood to cure her.
Emily Zimmerman, 16, of Aiken, has recurring brain tumors that have left her permanently blind and her family with mounting medical bills.
Both girls will benefit from a Fall Festival that will be held at The Hippodrome this weekend.
The Shepeard Blood Mobile will facilitate a blood drive at the festival, and all blood collected at the event will go to Shani, said Kitty Hall, one of the festival's organizers.
All proceeds from the festival will benefit the Zimmerman family, Hall said.
Phyllis Boyd, another organizer, nominated the Zimmermans to be the recipients after hearing their story.
The Zimmerman family lost their health insurance when Emily's mom lost her job.
Her father is a pastor and does not receive benefits, Boyd said.
Though her mom now has a new job, insurance will not cover Emily's surgeries because it is considered a pre-existing condition.
North Augusta Today was unable to reach either family.
Each year since the festival's inception four years ago, proceeds have been used to benefit a community member in need.
Organized primarily by Historic First Baptist Church of Beech Island, this year's festival will be held at The Hippodrome 10 a.m. to 4 p.m. Saturday and will feature a variety of activities.
Included are a car show, cake auction, barbecue cook-off, face painting, car show and free popcorn and cotton candy.
Admission to the event is free. Chicken dinners will be sold for $7 per plate. The Miss Heritage Day beauty pageant will be held Friday night at 6 p.m. and proceeds from that will benefit the Beech Island Historical Society.
Boyd said she is awed at the selfless outpouring of love from these churches to members of the community who are in need.
"I'm just in awe of people's good nature," she said. "We hate what it's for, but both little girls are very deserving of it"
Reach Lisa Kaylor at lisa.kaylor@northaugustatoday.com.
